| 4-氨基-1-萘甲腈的合成路线改进与结构表征 |
| |
| 引用本文： | 沈萍,覃宇.4-氨基-1-萘甲腈的合成路线改进与结构表征[J].武汉职业技术学院学报,2012,11(3):95-98. |
| |
| 作者姓名： | 沈萍 覃宇 |
| |
| 作者单位： | 武汉职业技术学院生物工程学院,湖北武汉,430074 |
| |
| 基金项目： | 湖北省教育厅科学技术研究计划指导性项目(B类)“4-氨基-1-萘甲腈的合成路线改进与结构表征” |
| |
| 摘 要： | 目的改进重要的医药化工中间体4-氨基-1萘甲腈的合成路线。方法以萘胺为原料，通过氨基保护、亲核取代、氨基去保护等步骤合成了该化合物，最终产率为81．6％。结果产物结构经过元素分析、IR和1HNMR表征，证实为目标分子。结论在分子结构中引入氰基-步中，采用L-脯氨酸为催化剂，CuCN为氰基化试剂，提高了氰基化效率，降低了对环境的危害。
|
| 关 键 词： | 4-氨基-1-萘甲腈 L-脯氨酸 氰基化反应 催化 |
Research on Improving Synthetic Route and Structural Characterization of 4 - amino -1- naphthalene Carbonitrile |
| |
| SHEN Ping,QIN Yu.Research on Improving Synthetic Route and Structural Characterization of 4 - amino -1- naphthalene Carbonitrile[J].Journal of Wuhan Institute of Technology,2012,11(3):95-98. |
| |
| Authors: | SHEN Ping QIN Yu |
| |
| Institution: | (School of Biological Engineering,Wuhan Polytechnic,Wuhan430074,China) |
| |
| Abstract: | The research aims to improve the synthetic route of 4-amino-1-naphthalene carbonitrile,which is an important pharmaceutical and chemical intermediate.The naphthylamine was used as raw materials;a compound was prepared by amino protection,nucleophilic substitution,amino unprotection and other steps.The total yield was 81.6%.Results show that the structure of the product was characterized by elemental analysis,IR and 1H NMR,which confirmed that was the target molecule.Thus,the paper concludes that in the process of introducing cyano into the molecular structure,when L-proline is used as catalyst,CuCN reagent for the cyano,the efficiency can be improved significantly and the harm to the environment can be reduced. |
| |
| Keywords: | 4-amino-l-naphthalenecabonitrile L-proline cyano reaction catalysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
