| 泛素-蛋白酶体系统在疼痛发生中的机制研究新进展 |
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| 引用本文： | 朱雅斌,李小静,孙灿林,钱涛.泛素-蛋白酶体系统在疼痛发生中的机制研究新进展[J].泰州职业技术学院学报,2012,12(3):62-63,78. |
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| 作者姓名： | 朱雅斌 李小静 孙灿林 钱涛 |
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| 作者单位： | 泰州市人民医院麻醉科,江苏泰州,225300 |
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| 摘 要： | 泛素-蛋白酶体系统是细胞内蛋白质降解的重要途径之一，它通过降解细胞内各通路的抑制因子和（或）激活因子发挥上调和下调作用，是维持细胞内许多生理功能的重要系统。近年来，有文献报道泛素一蛋白酶体系统由于参与抑制疼痛的细胞因子和蛋白质降解，从而成为神经性疼痛的重要发病因素。实验已经证实蛋白酶体抑制剂能够抑制神经性疼痛和痛觉过敏，从而进一步肯定了泛素-蛋白酶体系统在神经性疼痛发生机制中的作用。
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| 关 键 词： | 泛素-蛋白酶体 疼痛 神经性疼痛 |
Now Dovolopmont of Study on tho Ubiquitin-proteasome Systom in the Pain |
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| ZHU Ya-bin,LI Xiao-jing,SUN Can-lin,QIAN Tao.Now Dovolopmont of Study on tho Ubiquitin-proteasome Systom in the Pain[J].Journal of Taizhou Polytechnical Institute,2012,12(3):62-63,78. |
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| Authors: | ZHU Ya-bin LI Xiao-jing SUN Can-lin QIAN Tao |
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| Institution: | (Anaesthesia Department of Taizhou People’s Hospital,Taizhou Jiangsu 225300,China) |
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| Abstract: | The ubiquitin-proteasome is one of the important pathways of the protein degradation in the cells,and it acts the role of upregulating or downregulating by degradating the inhibitor or activator,and it is one of the important systems in maintaining the physiological function in cells.In recent years,some literatures report that the ubiquitin-proteasome is one of the important factors in the happening of the neuropathic pain because it degarades some of the cytokines and proteins which inhibit the pain.The experiments have proved that the proteasome inhibitor could inhibit the neuropathic pain and hyperalgesia,and confirm that ubiquitin-proteasome participate the neuropathic pain. |
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| Keywords: | ubiquitin-proteasome pain neuropathic pain |
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