Effect of nicorandil and amlodipine on bio-chemical parameters during isoproterenol induced myocardial necrosis in rats |
| |
| Authors: | Narinder Singh Rahat Kumar |
| |
| Institution: | (1) Deptt. Of Pharmacology, S. G. R. D. Inst. of Med. Sc. & Research, Amritsar;(2) S.G.R.D.Inst. of Med. Sc. & Research, Amritsar |
| |
| Abstract: | Objective To investigate the protective effect of nicorandil and amlodipine in isoproterenol induced myocardial necrosis in rats.
Methods The effect of nicorandil and amlodipine on bio-chemical parameters during isoproterenol induced myocardial necrosis in rats
was examined by determining the activity of creatine phosphokinase (CK), lactate dehydrogenase (LDH), and transaminases (AST,
ALT) in the serum of the animals.
Results Isoproterenol (150mg/kg/day) administered rats showed statistically significant rise in activities of LDH(1.02±0.19 to 1.85±0.05),
CK(4.3±0.19 to 7.37±.27), AST(0.38±.03 to 0.78±.05) and ALT(0.19±.017 to 0.346±.027) in the serum. Pre-co-treatment of rats
with nicorandil and amlodipine significantly lowered the raised levels of these enzymes and thereby restoring the enzyme activity
to near normal as was clear from the chart i.e. LDH was 1.10±0.04, CK was 4.37±0.19, AST and ALT were 0.39±0.028 and 0.199±0.04
respectively.
Conclusion It is demonstrated that pre-co-treatment with nicorandil and amlodipine either alone or in combination help in providing protective
effect on isoproterenol induced myocardial necrosis. |
| |
| Keywords: | creatine phosphokinase lactate dehydrogenase transaminases myocardial necrosis amlodipine nicorandil |
| 本文献已被 SpringerLink 等数据库收录！ |
|
