| 运动性蛋白尿与肾脏细胞凋亡之间关系的初探 |
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| 引用本文： | 陈伟,汤长发,唐凯.运动性蛋白尿与肾脏细胞凋亡之间关系的初探[J].四川体育科学,2004(2):33-36. |
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| 作者姓名： | 陈伟 汤长发 唐凯 |
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| 作者单位： | 1. 湖南师范大学体育学院,湖南,长沙,410081
2. 武汉体育学院,湖北,武汉,430079 |
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| 摘 要： | 运动性蛋白尿是1个古老的话题，但对其发生机制还未完全弄清楚。一般认为，肾缺血／再灌注期间产生的自由基是引起滤过膜通透性发生变化而导致蛋白尿的重要因素。在缺血／再灌注期间，ATP合成能力下降，P53、Bax等促凋亡基因表达上调，NO大量生成，细胞色素C、AIF外溢，从而导致细胞凋亡的发生，使肾小球、肾小管的功能衰退。故目前不少学者认为细胞凋亡是引发蛋白尿的1个重要的因素。
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| 关 键 词： | 运动性蛋白尿 肾脏细胞凋亡 自由基 形成原理 产生机制 肾缺血／再灌注期间 |
| 文章编号： | 1007-6891(2004)02-0033-04 |
A Simple Study of the Relation between Post-exercise Proteinuria and Kidney Cell Apoptosis |
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| CHEN Wel,TANG Chang-fa,Tong Kai . P. E. College of Hunan Normal University,Hunan Changsha,China, . Wuhan Institute of Physical Education,Hubei Wuhan,China..A Simple Study of the Relation between Post-exercise Proteinuria and Kidney Cell Apoptosis[J].Sichuan Sports Science,2004(2):33-36. |
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| Authors: | CHEN Wel TANG Chang-fa Tong Kai P E College of Hunan Normal University Hunan Changsha China Wuhan Institute of Physical Education Hubei Wuhan China |
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| Institution: | CHEN Wel1,TANG Chang-fa1,Tong Kai2 1. P. E. College of Hunan Normal University,Hunan Changsha,410081,China, 2. Wuhan Institute of Physical Education,Hubei Wuhan,430079,China. |
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| Abstract: | Post-exercise proteinuria is an old topic, but its exact mechanism has not been known thoroughly. It is generally acknowledged that during the exercise-induced ischemic/reperfusion, the permeability transition of filtration membrane that is triggered by the free radical is why the proteinuria is produced. During ischemic/reperfusion, with the expression of some genes, for example p53 and Bax, being improved a great deal, the production of Atp being reduced a lot, the amount of NO being added to, and CytC running out of motochondria, kidney cell apoptosis is unavoidable, the function of kidney is impaired as well. So today many scholars think kidney cell apoptosis may be one important factor that result in proteinuria. |
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| Keywords: | Proteinuria Apoptosis Kidney cell Relationship |
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