Copper and Zinc Status in Psoriasis: Correlation with Severity |
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| Authors: | Jyoti Aggarwal Akansha Singh Sanjeev Gupta Rajendra Prasad |
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| Institution: | 1.Department of Biochemistry, MMIMSR, Mullana, Ambala, India ;2.Department of Dermatology, MMIMSR, Mullana, Ambala, India |
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| Abstract: | Psoriasis is a common and an inflammatory skin disease. Trace elements play an important role in the skin metabolism such as keratinisation and melanin formation as well as immunological and inflammatory reactions. Henceforth, the present study was aimed to evaluate the essential metals with special reference to Cu and Zn. In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease. |
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| Keywords: | Psoriasis Trace elements Copper Zinc Oxidative stress PASI score |
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