| 粗粒化DNA穿孔行为的分子动力学模拟 |
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| 引用本文： | 马军.粗粒化DNA穿孔行为的分子动力学模拟[J].温州职业技术学院学报,2014,14(3):50-52. |
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| 作者姓名： | 马军 |
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| 作者单位： | 温州大学物理与电子信息工程学院,浙江温州,325035 |
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| 摘 要： | 核酸穿过核膜或细胞膜等穿孔行为,是重要的生命活动之一.为进一步了解核酸穿孔过程,建立DNA粗粒化模型,运用分子动力学方法模拟DNA穿孔行为.结果表明,孔长越长,孔内拉力越大,DNA链在孔外等待的时间越短,穿过孔所需的时间越短;但其中各因素的单独影响作用都比较有限;孔右侧力场对穿孔时间影响显著,一定条件下对穿孔过程起决定性作用.
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| 关 键 词： | 分子动力学 DNA 穿孔行为 粗拉化模型 |
Molecular Dynamics Simulation of Coarse-grained DNA Perforation Behavior |
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| MA Jun.Molecular Dynamics Simulation of Coarse-grained DNA Perforation Behavior[J].Journal of Wenzhou Vocational & Technical College,2014,14(3):50-52. |
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| Authors: | MA Jun |
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| Institution: | MA Jun (College of Physics and Electronic Information Engineering, Wenzhou University, Wenzhou, 325035, China) |
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| Abstract: | The perforation behavior of nucleic acid through the nuclear membrane or cell membrane is one of the important activities of the life. In order to further understand the perforation process of nucleic acid, a DNA coarse-grained model is set to simulate DNA perforation behavior by using the molecular dynamic method. The result shows that the longer the hole, the larger the pulling force within the hole, and the waiting time of the DNA chain outside the hole is shorter with shorter time for passing the hole. However, the individual impact of every element is comparatively limited. The force field on the right hole has a significant influence on perforation time and plays a decisive role on the perforation process in certain conditions. |
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| Keywords: | Molecular dynamics DNA Perforation behavior Coarse-grained model |
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