| Synthesis and characterization of degraded gelatin grafted poly(ɛ-caprolactone) copolymers |
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| 引用本文： | 冯亚凯,房子琛,王贺云,郭锦棠.Synthesis and characterization of degraded gelatin grafted poly(ɛ-caprolactone) copolymers[J].天津大学学报(英文版),2013,19(3):182-187. |
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| 作者姓名： | 冯亚凯 房子琛 王贺云 郭锦棠 |
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| 作者单位： | School of Chemical Engineering and Technology,Tianjin University |
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| 基金项目： | Supported by International Cooperation from Ministry of Science and Technology of China(No.2008DFA51170) |
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| 摘 要： | Hydrophilic degraded gelatin was modified with hydrophobic poly(ε-caprolactone) (PCL) via a chemical grafting route.Firstly,PCL with one hydroxyl end group was prepared by the ring-opening polymerization of εcaprolactone (ε-CL) with tin (Ⅱ) 2-ethylhexanoate as catalyst and n-butyl alcohol as initiator.Secondly,the PCL reacted with isophorone diisocyanate (IPDI) to prepare PCL with isocyanate functional group (PCL-NCO).Hydroxylamine was used to degrade gelatin by the cleavage between asparagine and glycine residues of gelatin.PCL-NCO reacted with the hydroxyl/amino groups of degraded gelatin in a homogeneous system and yielded the PCL modified gelatin copolymers.The gelatin grafted PCL copolymers were measured by means of XRD,FTIR,DSC and 1 H NMR.The results confirmed the conjugation of PCL onto gelatin chains.The PCL modified gelatin can be used as biomaterials owing to their biocompatibility and biodegradation.
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| 关 键 词： | degraded gelatin poly(ε-caprolactone) modification grafted copolymers biomaterials |
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