| 血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性 |
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| 引用本文： | 杜明艳,杜会山,周桔,丁文军.血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性[J].中国科学院研究生院学报,2010,27(1):133-137. |
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| 作者姓名： | 杜明艳 杜会山 周桔 丁文军 |
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| 作者单位： | 1. 北京潞河医院神经内科,北京,101149
2. 中国科学院研究生院生命科学学院,北京,100049 |
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| 摘 要： | 探讨汉族人群血管紧张素原(AGT)基因CD235Met-Thr变异与高血压合并脑梗塞发生的关系.采用突变基因分离聚合酶链反应(MS-PCR)方法检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的M235T等位基因型.BI组AGT基因T/T基因型频率和T等位基因频率(分别为0.720和0.811)显著高于C组(分别为0.516和0.700,P＜0.05)和EH组(分别为0.537和0.716,P＜0.05).结果提示,AGT基因CD235Met-Thr变异增加了汉族人群高血压合并脑梗塞发病的易感性.
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| 关 键 词： | 血管紧张素原基因 突变基因分离聚合酶链反应 高血压 脑梗塞 |
| 收稿时间： | 2009-05-15 |
| 修稿时间： | 2009-06-24 |
Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction |
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| DU Ming-Yan,DU Hui-Shan,ZHOU Ju,DING Wen-Jun.Relationship of angiotensinogen gene CD235Met-Thr variant and hypertension disease complicated with cerebral infraction[J].Journal of the Graduate School of the Chinese Academy of Sciences,2010,27(1):133-137. |
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| Authors: | DU Ming-Yan DU Hui-Shan ZHOU Ju DING Wen-Jun |
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| Institution: | 1. Department of Neurology, Luhe Hospital, Beijing 101149, China;
2. College of Life Sciences, Graduat University of the Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | The angiotensinogen (AGT) gene polymorphism was detected in the study of 82 cerebral infraction (BI) cases,67 simple essential hypertension (EH) cases,and 95 normal cases (control) using mutagenically separated PCR (MS-PCR) technique. The association of the AGT gene CD235Met-Thr variant and cerebral infraction (BI) in Chinese hypertension disease is evaluated. The frequencies of T/T genotype and T allele (0.720 and 0.811) in the BI group were significantly higher than those in the control group (0.516 and 0... |
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| Keywords: | angiotensinogen MS-PCR hypertension disease cerebral infraction |
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