| 基质金属蛋白酶-2在乳腺癌中的表达及与侵袭、转移的关系 |
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| 引用本文： | 任欣,陈英杰,陶雅军,刘健.基质金属蛋白酶-2在乳腺癌中的表达及与侵袭、转移的关系[J].大连大学学报,2002,23(6):99-101. |
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| 作者姓名： | 任欣 陈英杰 陶雅军 刘健 |
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| 作者单位： | 大连大学医学院,辽宁,大连,116622 |
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| 摘 要： | 目的]探讨乳腺癌细胞基质金属蛋白酶-2的表达及其与侵袭、转移的关系.方法]免疫组织化学方法检测60例乳腺癌患者癌组织中MMP-2表达.结果]MMP-2的表达在乳腺癌细胞明显高于正常乳腺细胞(P<0.01);淋巴结转移组明显高于非淋巴结转移组(P<0.01);在中、低分化组明显高于高分化组(P.<0.01).但与组织学类型无关(P<0.05).结果]乳腺癌的MMP-2的表达与其侵袭、转移可能相关.
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| 关 键 词： | 乳腺癌 基质金属蛋白酶-2 转移 |
| 文章编号： | 1008-2395(2002)06-0099-03 |
The expression of MMP- 2 in breast cancer from vessel and the relationship with invasiveness and metastasis |
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| REN Xin,CHEN Ying-jie,TAO Ya-jun,LIU Jian.The expression of MMP- 2 in breast cancer from vessel and the relationship with invasiveness and metastasis[J].Journal of Dalian University,2002,23(6):99-101. |
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| Authors: | REN Xin CHEN Ying-jie TAO Ya-jun LIU Jian |
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| Abstract: | Objective] To study the expression of MMP- 2 in breast cancer cells and the relationship with invasiveness and metastasis. Methods] The expression of MMP-2 in 60 breast cancer specimens was detected by immunohistochemical method. Results] The expression of MMP-2 in breast cancer cells was stronger than in normal breast cells (P<0.01). The expression of MMP-2 was significantly higher in cases with lymph node metastases than in those non-lymph node metastases(P<0.01). The expression of MMP-2 in G2-3 breast cancer was significantly higher than in G1(P<0.01). But no correlation between expression of MMP-2 and type of tissue was observed (P>0.05). Conclusion] The expression of MMP-2 in breast cancer correlate with invasiveness and metastasis. |
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| Keywords: | breast cancer MMP-2 metastasis |
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