| 耐力训练对非酒精性脂肪肝小鼠肝脏氧自由基代谢的影响 |
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| 引用本文： | 刘艳环,马国栋,刘克敏.耐力训练对非酒精性脂肪肝小鼠肝脏氧自由基代谢的影响[J].西安体育学院学报,2010,27(1). |
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| 作者姓名： | 刘艳环 马国栋 刘克敏 |
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| 作者单位： | 1. 山东理工大学体育学院,山东,淄博,255049
2. 大连医科大学,运动医学教研室,辽宁,大连,116027 |
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| 基金项目： | 山东理工大学博士启动基金资助项目 |
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| 摘 要： | 目的 探讨耐力训练对非酒精性脂肪肝肝脏抗氧化系统及活性氧生成的影响.方法 雄性8周龄ApoE基因敲除小鼠24只,西方膳食14周后,随机分为2组,非酒精性脂肪肝模型组(H,n=12,14周),跑台运动组(E,n=12,14+12周).跑台运动12周,坡度为0°,跑速13m/min,60min/time,每周5次.在造模与训练结束后,测定顺乌头酸酶、总SOD、MnSOD、CuZnSOD和GPx酶的活性;MDA、谷光甘肽(GSH)和羟自由基(OH-的含量;Mn-SOD、谷光甘肽过氧化物酶(GPx)和NF-кBmRNA的表达,光镜观察脂肪肝病变程度.结果 耐力训练显著提高总SOD、MnSOD、CuZnSOD、顺乌头酸酶和GPX酶的活性和肝脏GSH含量;显著降低CAT的活性及肝脏OH-和MDA的含量:显著上调MnSOD和NF-кBmRNA表达,GPxmRNA未见显著性改变.结论 耐力训练可以有效提高非酒精性脂肪肝肝脏抗氧化系统的能力,减少活性氧生成,从而达到改善非酒精性脂肪肝的效果.
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| 关 键 词： | 非酒精性脂肪肝 耐力训练 抗氧化系统 活性氧 |
Effect of Endurance Training on Metabolism of Oxygen Free Radicals in NAFLD of Mice |
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| LIU Yan-huan,MA Guo-dong,Liu Ke-min.Effect of Endurance Training on Metabolism of Oxygen Free Radicals in NAFLD of Mice[J].Journal of Xi'an Institute of Physical Education,2010,27(1). |
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| Authors: | LIU Yan-huan MA Guo-dong Liu Ke-min |
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| Institution: | LIU Yan-huan1,MA Guo-dong1,Liu Ke-min2(1.School of PE,Sh,ong University of Technology,Zibo 255049,China,2.Dalian Medical University,Dalian 116027,China) |
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| Abstract: | Objective To explore the effect of endurance training on the antioxidant defense system and the production of ROS of liver in NAFLD of ApoE-knockout mice Method Twenty four Eight-week ApoE-knockout mice were dieted western food for 14 weeks,whereafter randomly divided into two groups,H group and E group(all males).E group was trained on a treadmill for 60 minutes per day,5 days per week,0ograde(at 13 m/min).Every period ended,mice were sacrificed and liverwas saved for measuring activities of total SOD,MnSO... |
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| Keywords: | Nonalcohol fatty Liver endurance training Antioxidant defense system Reactive Oxygen species |
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