| SARS相关冠状病毒与其他已知冠状病毒的膜蛋白的多序列联配 |
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| 引用本文： | 史定华,周晖杰,王斌宾,顾燕红,王翼飞.SARS相关冠状病毒与其他已知冠状病毒的膜蛋白的多序列联配[J].上海大学学报(英文版),2003,7(2):118-123. |
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| 作者姓名： | 史定华 周晖杰 王斌宾 顾燕红 王翼飞 |
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| 作者单位： | DepartmentofMathematics，DepartmentofMathematics，DepartmentofMathematics，DepartmentofMathematics，DepartmentofMathematics ShanghaiUniversity，Shanghai200436，China，ShanghaiUniversity，Shanghai200436，China，ShanghaiUniversity，Shanghai200436，China，ShanghaiUniversity，Shanghai200436，China，ShanghaiUniversity，Shanghai200436，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina(GrantNo.70171059)andthe 863Project (GrantNo .2 0 0 2AA2 3 40 2 1) |
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| 摘 要： | 1 Introduction SARSisthefirstnewlyidentifiedseriousinfectiousdiseasethathumanbeingisfacingatthebeginningofthe 2 1stcentury .Ithasbeen primarilyrecognizedthatavariantofvirusfromthecoronavirusfamilymightbethecandidatepathogenofSARS ,asreportedbyWHO (WorldHealthOrganization)onApril 2 9,2 0 0 3(http ://www .who .int/csr/sarscountry/en) . Coronaviruseswerefirstisolatedfromchickensin1937.Therearenowapproximately 15speciesinthisfamily.Coronavirusparticlesareirregularlyshaped ,roundabout 6 0 …
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| 关 键 词： | SARS病毒 冠状病毒 蛋白质 氨基酸序列 隐式马尔可夫模型 非典型肺炎 |
| 收稿时间： | 22 May 2003 |
Multiple sequence alignment of the M protein in SARS-associated and other known coronaviruses |
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| Shi?Ding-Hua,Zhou?Hui-Jie,Wang?Bin-Bin,Gu?Yan-Hong,Wang?Yi-Fei.Multiple sequence alignment of the M protein in SARS-associated and other known coronaviruses[J].Journal of Shanghai University(English Edition),2003,7(2):118-123. |
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| Authors: | Shi Ding-Hua Zhou Hui-Jie Wang Bin-Bin Gu Yan-Hong Wang Yi-Fei |
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| Institution: | Department of Mathematics, Shanghai University, Shanghai 200436, China |
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| Abstract: | In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS associated and 6 others known). The alignment model was based on the profile HMM (Hidden Markov Model), and the model training was implemented through the SAHMM (Self Adapting Hidden Markov Model) software developed by the authors. |
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| Keywords: | SARS (Severe Acute Respiratory Syndrome) coronavirus M (Membrane or Matrix) protein multiple sequence alignment profile HMM |
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