| 度洛西汀与阿米替林治疗卒中后抑郁症比较分析 |
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| 引用本文： | 徐莉,;胡国平.度洛西汀与阿米替林治疗卒中后抑郁症比较分析[J].孝感职业技术学院学报,2014(2):110-112. |
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| 作者姓名： | 徐莉 ;胡国平 |
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| 作者单位： | [1]湖北省荣军医院,湖北武汉430071; [2]湖北职业技术学院医学分院,湖北孝感432000 |
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| 摘 要： | 目的：探讨脑卒中后抑郁症（post stroke depression,PSD）的发生率、临床特点及度洛西汀干预治疗效果.方法：对2010年3月至2012年12月住院及门诊确诊为脑卒中并发抑郁症的58例患者进行统计分析,在治疗脑卒中的同时随机分成治疗组和对照组,分别给予度洛西汀和阿米替林治疗.结果：脑卒中后抑郁症发生率为42.6％,其发生率与卒中类型及卒中的病灶部位无关,两组药物均能快速起效,治疗1、2、4、8周后HAMD评分较治疗前差异有统计学意义（P＜0.05）,两组药物HAMD评分无统计学意义（P＞0.05）,不良反应TESS评分有统计学意义（P＜0.05）.结论：脑卒中后抑郁症为脑卒中常见并发症,应重视卒中后抑郁症的预防和治疗.度洛西汀治疗PSD安全有效,值得进一步推广.
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| 关 键 词： | 脑卒中 抑郁症 度洛西汀 阿米替林 |
A Comparative Study between Dutoxetine and Amitriptyline in Treatment of Post-stroke Depression |
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| Institution: | XU Li1, HU Guo -ping2 (1. Hubei Rongjun Hospital, Wuhan, 2. Medical School of Hubei Polytechnic Institute, Hubei 430071, China ; Xiaogan, Hubei 432000, |
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| Abstract: | Objective ： To investigate the incidence, characteristics of Post - stroke Depression （PSD） and the efficiency of treatment with Dutoxetine. Methods ： Statistical analysis of 58 outpatients and inpatients diagnosed as PSD from March 2010 to December 2012 was taken. 58 patients were randomly divided into treatment group （Du- toxetine group） and control group （Amitriptyline group） while they were accepting routine treatment. Results： The incidence rate of PSD was 42.6%, and it was not associated with the types and nidus of stroke. Both of the two groups acted rapidly, and more significant difference was shown in the HAMD scores after 1,2, 4, 8 weeks than that before. No statistical significance（ P 〉 0.05） was found in the HAMD scores of two groups, but statistical significance was found in the two groups＇adverse effect Tess scores （P 〈 0.05 ）. Conclusions： PSD is a common complication of stroke. The prevention and therapy should be paid more attention to. Dutoxetine deserves to be further promoted be- cause of its safety and efficiency in PSD treatment. |
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| Keywords: | post - stroke depression Dutoxetine Amitriptyline |
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