Antioxidant status in neonatal jaundice before and after phototherapy |
| |
| Authors: | Kiran Dahiya A D Tiwari Vijay Shankar Simmi Kharb Rakesh Dhankhar |
| |
| Institution: | (1) Department of Biochemistry, Pt.B.D. Sharma PGIMS, H. No. 20, Subhash Nagar, PIN-124001 Rohtak, Haryana, India;(2) Department of Pediatrics, Pt.B.D. Sharma PGIMS, H. No. 20, Subhash Nagar, PIN-124001 Rohtak, Haryana, India;(3) Department of Radiotherapy, Pt.B.D. Sharma PGIMS, H. No. 20, Subhash Nagar, PIN-124001 Rohtak, Haryana, India |
| |
| Abstract: | Phototherapy has been related to increased oxidative stress and lipid peroxidation. In the present study, thirty full term
jaundiced neonates with appropriate weight were analyzed before and after completion of phototherapy for malondialdehyde (MDA),
reduced glutathione (GSH), total thiols, vitamin C and superoxide dismutase (SOD) levels in hemolysate and albumin levels
in plasma. These parameters were analyzed in cord blood samples of 20 healthy neonates as control. It was observed that levels
of MDA were elevated significantly (p<0.001) in patients as compared to controls and that the levels increased significantly
after phototherapy (p<0.001). Levels of SOD were also found to be increased significantly as compared to controls and the
levels rose after phototherapy (p<0.001). On the other hand, the levels of non-enzymatic antioxidants such as GSH, total thiols
and vitamin C were significantly low (p<0.001) as compared to controls and the levels decreased significantly after phototherapy
(p<0.001). The plasma albumin levels also were found to be decreased significantly after phototherapy (p<0.01). Therefore,
phototherapy increases oxidative stress and should be used with care. |
| |
| Keywords: | Neonatal Jaundice Oxidative stress Phototherapy |
| 本文献已被 SpringerLink 等数据库收录！ |
|
