An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy |
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| Authors: | Anmol Goyal Rajendra Prasad Parul Goel Amit Pal Suvarna Prasad Isha Rani |
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| Institution: | 1.Department of Community Medicine, Gian Sagar Medical College and Hospital, Ram Nagar, Rajpura, Patiala, Punjab India ;2.Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Maharishi Markandeshwar University (MMU), Mullana, Ambala, Haryana, India ;3.Department of Biochemistry, AIIMS, Kalyani, West Bengal 741235 India |
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| Abstract: | Coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease which has affected more than 6.2 million people globally, with numbers mounting considerably daily. However, till date, no specific treatment modalities are available for Covid-19 and also not much information is known about this disease. Recent studies have revealed that SARS-CoV-2 infection is associated with the generation of thrombosis and coagulopathy. Fundamentally, it has been believed that a diverse array of signalling pathways might be responsible for the activation of coagulation cascade during SARS-CoV-2 infection. Henceforth, a detailed understanding of these probable underlying molecular mechanistic pathways causing thrombosis in Covid-19 disease deserves an urgent exploration. Therefore, in this review, the hypothetical crosstalk between distinct signalling pathways including apoptosis, inflammation, hypoxia and angiogenesis attributable for the commencement of thrombotic events during SARS-CoV-2 infection has been addressed which might further unravel promising therapeutic targets in Covid-19 disease. |
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| Keywords: | SARS-CoV-2 Covid-19 Coagulopathy Hypoxia Apoptosis Inflammation Angiogenesis |
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