| 神经生长因子对大鼠脑缺血再灌注后HIF-1α及HSP70表达的影响 |
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| 引用本文： | 张蕾,辛世萌.神经生长因子对大鼠脑缺血再灌注后HIF-1α及HSP70表达的影响[J].大连大学学报,2009,30(3):103-107. |
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| 作者姓名： | 张蕾 辛世萌 |
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| 作者单位： | 大连大学附属中山医院,辽宁大连,116001 |
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| 摘 要： | 采用大鼠大脑中动脉（MCAO）模型，肌肉内注射神经生长因子（NGF），经过免疫组化和HE染色检测Sprague—Dawley（SD）大鼠脑缺血再灌注后HIF-1α（缺血诱导因子）及HSP70（热休克蛋白70）表达的变化及神经生长因子的影响。结果表明，肌肉注射神经生长因子对脑缺血再灌注有明显的保护作用，HIF—1α及HSP70表达增加可能是其机制之一。
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| 关 键 词： | 局灶性脑缺血／再灌注 神经生长因子 大鼠 |
Effect of nerve growth factor on expression of hypoxia-inducible factor 1 in rat after cerebral ischemical reperfusion |
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| ZHANG Lei,XIN Shi-meng.Effect of nerve growth factor on expression of hypoxia-inducible factor 1 in rat after cerebral ischemical reperfusion[J].Journal of Dalian University,2009,30(3):103-107. |
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| Authors: | ZHANG Lei XIN Shi-meng |
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| Institution: | ZHANG Lei, XIN Shi - meng (Affiliated Zhongshan Hospital of Dalian Vniversity , Dalian 116001 China ) |
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| Abstract: | Applying middle cerebral artery occlusion model of rat and injecting nerve growth factor in muscle and staining with immunohistochemical method and HE method to observe the change of expression of hypoxia-inducible factor1(HIF-1α) and heat shock broken 70(HSP70) and the effect of nerve growth factor on it after focal cerebral ischemical reperfusion injury in Sprague-Dawley(SD) rat.The expression of heat shock broken 70 increased after cerebral ischemical,reperfusion injury and peaked at 24th hour,and reduced by then.Compared with the group of ischemical reperfusion,the expression of heat shock broken 70 increased after injection of nerve growth factor in rats,(P〈0.01).The results implied that injection nerve growth factor in muscle was protective effect clearly on cerebral ischemical reperfusion injury.The increasing of expression of hypoxia-inducible factor and heat shock broken 70 is the principle probably. |
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| Keywords: | Focal cerebral ischemical reperfusion Nerve growth factor Rat |
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