| 一氧化氮在有氧运动大鼠股四头肌过氧化应激及JNK表达中的作用 |
| |
| 引用本文： | 秦春霞,钱海,车力龙,秦从军,陈谦,肖德生.一氧化氮在有氧运动大鼠股四头肌过氧化应激及JNK表达中的作用[J].沈阳体育学院学报,2011,30(1):58-61. |
| |
| 作者姓名： | 秦春霞 钱海 车力龙 秦从军 陈谦 肖德生 |
| |
| 作者单位： | 1. 江苏大学,基础医学与医学技术学院,江苏,镇江,212013
2. 广州医学院,公共卫生与全科医学学院,广东,广州,510182 |
| |
| 摘 要： | 目的:探讨有氧运动后一氧化氮(NO)对股四头肌的过氧化应激及MAPK通路的调控作用。方法:大鼠分为静息组(SED)、运动组(EXE)、静息+NOS抑制组(SED-LNAME)、运动+NOS抑制组(EXE-LNAME)。运动组及运动+NOS抑制组每周连续游泳5d。共持续3个月。观察大鼠股四头肌MDA、SOD、TAOC及JNK水平的变化。结果:与SED组比较,EXE组大鼠股四头肌SOD、TAOC、p-JNK蛋白显著升高,在应用L-NAME干预后,运动+NOS抑制组MDA升高,SOD、TAOC、p-JNK显著下降,t-JNK无显著性变化。结论:运动训练诱导产生的NO可能介导JNK信号激酶诱导抗氧化酶产生,从而提高骨骼肌的抗氧化能力。
|
| 关 键 词： | 运动 抗氧化 NO JNK |
Role of Nitric Oxide in Oxidative Stress and JNK Expression of Quadriceps Femoris of Rats in Aerobic Exercise |
| |
| QIN Chunxia,QIAN Hai,CHE Lilong,QIN Congjun,CHEN Qian,XIAO Desheng.Role of Nitric Oxide in Oxidative Stress and JNK Expression of Quadriceps Femoris of Rats in Aerobic Exercise[J].Journal of Shenyang Sport University,2011,30(1):58-61. |
| |
| Authors: | QIN Chunxia QIAN Hai CHE Lilong QIN Congjun CHEN Qian XIAO Desheng |
| |
| Institution: | 1.School of Medical Science and Laboratory Medicine,Jiangsu University,Zhenjiang 212013,Jiangsu,China; 2.School of Public Health and General Practice,Guangzhou Medical University,Guangzhou 510182,Guangdong,China) |
| |
| Abstract: | Objective:To investigate the role of NO(nitric oxide) in oxidative stress and the MAPK pathways of quadriceps femoris in long-term aerobic exercise.Methods:Rats were divided into a sedentary group(SED),an exercise group(EXE),a sedentary plus L-NAME group(SED-LNAME) and an exercise plus L-NAME group(EXE-LNAME).The rats in the EXE group and EXE plus LANME group swam for 5 days in a week,lasting for 3 months,and then the levels of MDA(malonaldehyde),SOD(Superoxide Dismutase),TAOC(total antioxidant capacity) and JNK(c-Jun N-terminal kinase) in the quadriceps femoris were analyzed.Results:Compared with the sedentary group,the contents of SOD,TAOC and p-JNK(phosphorylation-JNK) of the exercise group were significantly increased in quadriceps femoris.Treatment with L-NAME led to an increase in the MDA content,a significant decrease in the SOD,TAOC and p-JNK levels,without significant changes of the level of t-JNK in the EXE-LNAME group.Conclusion:During long-term aerobic exercise,NO may improve antioxidant capacity in skeletal muscle by increasing antioxidant enzymes activities,possibly through activating the JNK pathway. |
| |
| Keywords: | NO JNK |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
