Effect of hemodialysis on circulating cystatin c levels in patients with end stage renal disease |
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| Authors: | N Krishnamurthy K Arumugasamy U Anand C V Anand V Aruna G Venu R Gayathri |
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| Institution: | 1.Department of Biotechnology,Sathyabama University,Chennai,India;2.Department of Biochemistry,PSG Institute of Medical Sciences and Research,Coimbatore,India;3.Department of Nephrology,PSG Institute of Medical Sciences and Research,Coimbatore,India;4.Department of Molecular Biotechnology,Washington University,Washington DC,USA;5.Department of Biochemistry,PSG Institute of Medical Sciences and Research,Coimbatore,India |
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| Abstract: | Plasma cystatin C is an emerging parameter to assess kidney function. Its utility in assessing the adequacy of hemodialysis
in patients with end-stage-renal disease has however not been established with certainty. This study was therefore carried
out to assess the usefulness of serum cystatin C estimation in patients undergoing low flux membrane hemodialysis. Serum creatinine
and cystatin C were estimated in 20 patients before and after undergoing hemodialysis. The mean serum creatinine decreased
from a pre-dialysis value of 7.72 mg/dL to a post-dialysis value of 2.90 mg/dL. On the contrary, the mean serum cystatin C
levels were found to increase from a pre-dialysis value of 5.97 mg/L to a post-dialysis value of 8.25 mg/L. Therefore, serum
cystatin C cannot be used to monitor dialysis adequacy. It however, serves as a surrogate marker of the inadequacy of low
flux membrane bicarbonate hemodialysis in clearing low molecular weight proteins from the circulation. |
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