| 有氧运动对ApoE基因缺陷小鼠主动脉脂联素受体1蛋白表达的影响 |
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| 引用本文： | 吴卫东,荆西民,岳静静.有氧运动对ApoE基因缺陷小鼠主动脉脂联素受体1蛋白表达的影响[J].中国体育科技,2012(1):116-118. |
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| 作者姓名： | 吴卫东 荆西民 岳静静 |
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| 作者单位： | 郑州大学体育学院;河南机电职业学院 |
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| 摘 要： | 目的:研究运动对ApoE-/-小鼠主动脉脂联素受体1蛋白表达的影响。方法:8周龄雄性ApoE-/-小鼠随机分为安静组(C)和运动组(E)。两组小鼠均饲以高脂饲料,C组不训练,E组进行14周跑台运动。14周末取材比较两组小鼠主动脉管壁的病理变化,检测比较其脂肪组织脂联素mRNA表达水平、血清脂联素水平及主动脉脂联素受体1蛋白表达水平。结果:与C组小鼠相比,E组小鼠主动脉管壁纤维弹力板和内膜较完好,脂肪组织脂联素mRNA表达、血清水平及主动脉脂联素受体1蛋白表达均显著增加。结论:14周有氧运动显著提高了小鼠脂肪组织脂联素mRNA表达、血清脂联素水平及主动脉脂联素受体1的蛋白表达,这可能是有氧运动防治动脉粥样硬化的重要机制之一。
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| 关 键 词： | 运动 ApoE-/-小鼠 脂联素 脂联素受体1 |
Effect of Aerobic Exercise on Expression of Adiponectin Receptor 1 in ApoE Deficient Mice Aorta |
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| WU Wei-dong,JING Xi-min,YUE Jing-jing.Effect of Aerobic Exercise on Expression of Adiponectin Receptor 1 in ApoE Deficient Mice Aorta[J].China Sport Science and Technology,2012(1):116-118. |
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| Authors: | WU Wei-dong JING Xi-min YUE Jing-jing |
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| Institution: | 1.Zhengzhou University,Zhengzhou 450044,China;2.Henan Mechanical and Electrical Vocational College,Zhengzhou 451191,China. |
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| Abstract: | Objective:The purpose of the present experiment is to observe the change of adiponectin receptor 1 in aorta.Methods:8-week-old ApoE deficient mice were randomly assigned to two groups:ApoE deficient mice control group(C);aerobic exercise-trained group(E).The mice were fed by high fat diet.Mice in the aerobic exercise-trained groups ran on a treadmill for a total of 14 weeks.At the end of experiment,atherosclerotic was observed.Adiponectin mRNA in adipose tissue and serum adiponectin was tested.Adiponectin receptor 1 protein in aortic was detected.Results:The results showed that vascular of E group was significantly better than C group;Adiponectin-mRNA in the adipose tissue,serum Adiponectin and adiponectin receptor 1 protein of E group were significantly higher than that of the C group.Conclusion:It suggests that 14 weeks aerobic exercise can significantly increase adiponectin-mRNA in the adipose tissue,serum adiponectin as well as adiponectin receptor 1 protein.Aerobic exercise is likely to be one of the factors to anti-atherogenesis. |
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| Keywords: | exercise ApoE deficient mice adiponectin AdipoR1 |
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