| How variable progenitor clones construct a largely invariant neocortexOA |
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| 作者姓名： | Zhongfu Shen Jiajun Yang Qiangqiang Zhang Kuiyu Wang Xiaohui Lv Xiaolin Hu Jian Ma Song-Hai Shi |
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| 作者单位： | 1. New Cornerstone Science Laboratory, IDG/McG overn Institute for Brain Research, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University;2. Department of Computer Sciences, Tsinghua University;3. College of Life Sciences, Nankai University |
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| 基金项目： | the National Natural Science Foundation of China (32021002)； |
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| 摘 要： | The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of ...
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