Multiple Myeloma: A Case of Atypical Presentation on Protein Electrophoresis |
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| Authors: | Nihar Ranjan Dash Biswajit Mohanty |
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| Institution: | (1) Department of Biochemistry, Apollo Hospitals, Bhubaneswar, India; |
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| Abstract: | Multiple myeloma is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin
(M-protein). Protein electrophoresis is advised whenever multiple myeloma is suspected. The monoclonal protein migrates as
a single entity in the electric field and is detected by the non-specific protein stain as a more intensely stained band superimposed
on the usual protein pattern. The M-protein usually migrates in the gamma or beta region of the normal protein pattern; very
rarely it may appear in the α2 or even in α1 region. Here we have given an atypical case presentation where the patient with
multiple myeloma presented with two M-spike one each in α2 and β-globulin region on agarose gel protein electrophoresis with
hypoglobulinemia but with reversed A:G ratio. |
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| Keywords: | Multiple myeloma M-protein Agarose gel protein electrophoresis Immunofixation electrophoresis Biclonal gammopathy |
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