| 阿魏酸钠对高脂饮食致动脉粥样硬化的作用 |
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| 引用本文： | 张敬芳,杨雪琴,王光浩.阿魏酸钠对高脂饮食致动脉粥样硬化的作用[J].荆门职业技术学院学报,2004,19(6):72-74. |
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| 作者姓名： | 张敬芳 杨雪琴 王光浩 |
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| 作者单位： | 荆门职业技术学院医学院 湖北荆门448000
(张敬芳，杨雪琴)，荆门市第二人民医院 湖北荆门448000(王光浩) |
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| 基金项目： | 湖北省教育厅科研项目《阿魏酸钠对血管内皮细胞的作用及其机制的研究》，项目编号2002C39. |
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| 摘 要： | 目的:探讨阿魏酸钠(SF)抗动脉粥样硬化(AS)的作用及其机理.方法:18只家兔随机分为三组:对照组、高脂组、SF组.分别给予普通饲料、高脂饲料、高脂饲料加SF.10周末颈动脉放血取血样后,处死动物,检查血脂、观察主动脉粥样硬化斑块变化、主动脉超微结构.结果:⑴高脂组和SF组血脂含量显著高于对照组,SF组甘油三脂(TG)含量显著低于高脂组(P<0.05);⑵SF组AS斑块显著低于高脂组(P<0.01);⑶电镜结果显示SF组主动脉损伤明显减轻.结论:SF具有明显的抗AS形成的作用,其机制是:降低血中TG含量,保护内皮细胞.
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| 关 键 词： | SF 高脂饮食 阿魏酸钠 对照组 主动脉 TG 动脉粥样硬化 饲料 家兔 斑块 |
| 文章编号： | 1008-4657(2004)06-0072-03 |
| 修稿时间： | 2004年2月12日 |
The Function of Sodium Ferulae on Atherosclerosis Caused by High Fat Food |
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| ZHANG Jing-fang,YANG Xue-qin,WANG Guang-hao.The Function of Sodium Ferulae on Atherosclerosis Caused by High Fat Food[J].Journal of Jingmen Vocational Technical College,2004,19(6):72-74. |
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| Authors: | ZHANG Jing-fang YANG Xue-qin WANG Guang-hao |
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| Institution: | ZHANG Jing-fang~1,YANG Xue-qin~1,WANG Guang-hao~2 |
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| Abstract: | Aims: probe into the function and mechanism of sodium ferulae on ant-atherosclerosis. Methods: 18 domestic rabbits are divided into three groups at random: the contrast group, high fat group and sodium ferulae group. The rabbits in each group are respectively fed on by common food, high fat food and high fat food with sodium ferulae .At the end of the tenth week ,draw out blood samples from carotid artery of the rabbits and then kill them, analyze the blood fat, observe the variations of the atherosclerosis spots and super micro structure of aorta .Results:(1)The containing of blood fat in high fat group and sodium ferulae group is obviously higher than that in common group .The containing of triglycerin in sodium ferulae groups is obviously lower than that in high fat group(P<0.05) ;(2)The atherosclerosis spot in sodium ferulae group is obviously lower than that in high fat group(P<0.01);(3)The result in electric microscope shows that the damage to aorta is obviously alleviative. Conclusion: Obviously, sodium ferulae has the function of anti-atherosclerosis formation, the mechanism of which is that sodium ferulae can protect endothelial cell by lowering the containing of triglyceride. |
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| Keywords: | sodium ferulae atherosclerosis triglyceride |
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