| 运用螺旋理论推断秋水仙碱的构型 |
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| 引用本文： | 尹玉英,刘春蕴.运用螺旋理论推断秋水仙碱的构型[J].中国科学院研究生院学报,2004,21(2):164-167. |
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| 作者姓名： | 尹玉英 刘春蕴 |
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| 作者单位： | 北京石油化工学院,北京 102600 |
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| 基金项目： | 国家自然科学基金资助项目 ( 2 95 42 0 0 6) |
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| 摘 要： | 秋水仙碱是医治癌症的重要药物 ,其结构中不仅存在手性碳原子的构型问题 ,也存在类似于联苯衍生物的构型和构象问题 .确定了手性碳原子的构型 ,还必须确定两个芳环间的构型和构象 .运用笔者提出的螺旋理论 ,通过其旋光方向和旋光度可以方便地确定秋水仙碱两个芳环间的构型和构象 .
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| 关 键 词： | 构型 秋水仙碱 螺旋理论 |
| 文章编号： | 1002-1175(2004)02-0164-04 |
| 修稿时间： | 2003年1月20日 |
Prediction of Configuration for the Colchicine on the Basis of the Helix Theory |
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| YIN Yu-Ying,LIU Chun-Yun.Prediction of Configuration for the Colchicine on the Basis of the Helix Theory[J].Journal of the Graduate School of the Chinese Academy of Sciences,2004,21(2):164-167. |
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| Authors: | YIN Yu-Ying LIU Chun-Yun |
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| Abstract: | The colchicine is an important medicine for cancer.There are not only configurational problems of chiral carbon atom but the problems of configuration and conformation similar to the biphenyl derivatives.The configuration and conformation between the two aromatic rings need to be determined after the configuartion of chiral carbon atom is determined.According to the helix theory proposed by the authors,the configuration and conformation between the two aromatic rings of colchicine can be conveniently deduced from its rotatory direction and value of rotation. |
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| Keywords: | colchicine configuration helix theory |
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