Substrate channelling |
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| Authors: | Danish Khan |
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| Institution: | 1. School of Biotechnology, Banaras Hindu University, Varanasi, 221 005, India
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| Abstract: | The fascinating process of channelling of metabolic intermediates through enzymes is discussed in this article. Often, the active sites of two enzymes that catalyse sequential reactions in a metabolic pathway are connected through an intra-molecular ??void?? ?? a sort of tunnel, lined by amino acids through which intermediates pass. Synergy between the subunits leads to a phenomenal increase in the overall rate of catalysis. There are enzymes with a single channel, some with multiple channels and some without any discrete channel/s, yet achieving high catalytic rates. Unravelling details about these natural tunnels of angstromdimensions has evoked great interest and curiosity in biochemists all over the world. |
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