Diagnostic strategies for subclinical hypothyroidism |
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| Authors: | Shruti Mohanty W Amruthlal G C Reddy G Kusumanjali A S Kanagasabapathy Pragna Rao |
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| Institution: | (1) Department of Biochemistry, Kamineni Institute of Medical Sciences, Narkatpally, Nalgonda District, A.P. 508 254, India;(2) Department of ENT, Kamineni Institute of Medical Sciences, Narkatpally, Nalgonda District, A.P. 508 254, India |
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| Abstract: | The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are
clinically symptomatic but may have a normal thyroid profile. Tri — iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples
from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO
levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels
(73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk
of developing overt hypothyroidism. |
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| Keywords: | Hypothyroidism Thyroid Profile T3 T4 TSH Anti TPO |
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