Nitric oxide: A useful indicator in acute allograft rejection after liver transplantation |
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| Authors: | Vaishali N Thorat Adinath N Suryakar Pradeep Nailk Bipin M Tiwale |
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| Institution: | (1) Department of Biochemistry, Dr. D. Y. Patil Medical College, Kolhapur, India;(2) RCSM Govt. Medical College, Kolhapur, India;(3) Global Hospitals, Hyderabad, India;(4) Department of Biochemistry, RCSM Govt. Medical College, Shendapark, Kolhapur, 416410, India |
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| Abstract: | The aim of this study was to monitor serum nitric oxide levels at various times, intraoperatively and following liver transplantation
in humans. Nitric oxide production was assessed by cadmium reduction method in 15 patients undergoing liver transplantation.
We observed strong correlation between nitric oxide production and allograft rejection. Sustained rise in nitric oxide level
after transplantation might provide an indication of acute allograft rejection. Therefore measurement of nitric oxide, a stable
end product appears to be an excellent marker that can help in the development of strategies intended to improve graft viability
and patient’s survival. |
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| Keywords: | Ischemia/reperfusion injury Nitric oxide Allograft rejection Nitric oxide synthase |
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