| 正交试验联用星点设计-效应面法优化西瓜皮总黄酮提取工艺研究 |
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| 引用本文： | 王章姐,张梦茹.正交试验联用星点设计-效应面法优化西瓜皮总黄酮提取工艺研究[J].宜春学院学报,2014,36(9):91-93. |
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| 作者姓名： | 王章姐 张梦茹 |
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| 作者单位： | 安徽新华学院药学院,合肥,230088 |
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| 基金项目： | 安徽新华学院自然科学项目 |
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| 摘 要： | 以总黄酮得率为指标，采用正交试验联合星点设计-效应面法考察乙醇体积分数、提取时间和固液比对西瓜皮总黄酮提取工艺的影响。结果表明正交试验确定最佳提取工艺为30倍量90％乙醇，提取3次，每次120min；星点设计一效应面法确定最佳提取工艺为14.22倍量71.17％乙醇，提取3次，每次48.25min。通过星点设计-效应面法优选的工艺合理可行，且比正交试验设计法更为准确。
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| 关 键 词： | 西瓜皮 总黄酮 正交设计 星点设计-效应面法 提取工艺 |
Optimization of Extraction Technology of Total Flavonoids from Watermelon Peel on Central Composite Design-Response Surface Methodology and Orthogonal Design |
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| WANG Zhang-jie,ZHANG Meng-ru.Optimization of Extraction Technology of Total Flavonoids from Watermelon Peel on Central Composite Design-Response Surface Methodology and Orthogonal Design[J].Journal of Yichun University,2014,36(9):91-93. |
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| Authors: | WANG Zhang-jie ZHANG Meng-ru |
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| Institution: | WANG Zhang - jie, ZHANG Meng - ru (School of Pharmaceutical Sciences, Anhui Xinhua College, Hefei 230088, China) |
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| Abstract: | With the extraction rate of total flavonoids from Watermelon Peel as index, central composite design - response surface methodology and orthogonal design were adopted to optimize extraction technology by taking ethanol concentration, extraction time and solid - liquid ratio as factors. Optimum process determined by orthogonal design was as following： extracted 3 times with 30 times the amount of 90% ethanol, 120 min per time; The best process optimized by central composite design - response surface methodology was as following： extracted 3 times with 14.22 times the amount of 71.17% ethanol, 48.25 min per time. The optimizied technology was reasonable and feasible with good predictability, and more accurate than the orthogonal experiment design method. |
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| Keywords: | Watermelon Peel Total Flavonoids Orthogonal Design Central Composite Design - Response Surface ExtractionTechnology |
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