Early detection of prostate cancer: evaluating the diagnostic performance of prostate specific antigen by comparing with histological technique among africans |
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| Authors: | Emokpae M A Das S C Orok T Mohammed A Z Hassan S A |
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| Institution: | (1) Dept of Pathology, Aminu Kano Teaching Hospital, Kano, Nigeria;(2) Dept of Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria;(3) Head, Dept., of Chemical Pathology, Aminu Kano Teaching Hospital, PMB 3452, 700001 Kano, Nigeria |
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| Abstract: | This study was conducted to investigate the diagnostic performance characteristics of prostate specific antigen (PSA) by comparing
serum PSA value with histological findings in patients suspevted of having prostate cancer in Aminu Kano Teaching Hospital.
Nigeria. Clinical and Laboratory records were examined and collated for serum PSA values, together with histological findings
of biopsy specimen, clinical diagnosis, age of patients, and mode of presentation. The serum PSA values were determined by
ELECSYS 1010 autoanalysers Roche, Germany based on electrochemiluminescence immunoassay technique. The results show that serum
PSA values increase with age in the assymptomatic non-cancer patients who came for medical check up but were within normal
limit. In prostatic disease conditions PSA values were raised in benign prostatic hyperplasia 35.957± 4.0315ng/ml, in undifferentiated
carcinoma 56.22±4.295ng/ml and adenocarcinoma >100ng/ml as compared to the normal range (0–4ng/ml). These cases were confirmed
by histological diagnosis. It is concluded that PSA evaluations is a sensitive marker for prostate cancer but because of various
other conditions that affect serum PSA concentration, other methods of investigations such as Digital Rectal examination,
Trans Urethral Ultra-Sonography and histological examination should be combined to confirm diagnosis. Prognosis of patients
will be better if early diagnosis is made. |
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| Keywords: | Prostate specific antigen Africans |
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