| 依托度酸双层渗透泵控释片的制备 |
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| 引用本文： | 常明,岳红坤,牟微,李超,刘树彬.依托度酸双层渗透泵控释片的制备[J].石家庄学院学报,2011,13(3):14-17,78. |
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| 作者姓名： | 常明 岳红坤 牟微 李超 刘树彬 |
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| 作者单位： | 石家庄学院化工学院,河北石家庄,050035 |
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| 摘 要： | 目的:制备依托度酸双层渗透泵控释片.方法:采用单因素法考察依托度酸渗透泵控释片体外释药行为的影响.结果:最佳片剂处方组成为:包衣膜增重为15%,聚氧乙烯(PEO)65%,CMS-Na 56 mg,HPMCK100M 45 mg,CP971NF 11.6 mg,PVPK30 22 mg,NaCl 32.5 mg.控释片批间重复性良好.结论:自制依托度酸双层渗透泵控释片工艺稳定,零级释药特征明显,24 h内释药完全.
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| 关 键 词： | 依托度酸 渗透泵 单因素实验 |
Preparation of Etodolac Double-layer Osmotic Pump Controlled Release Tablet |
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| CHANG Ming,YUE Hong-kun,MU Wei,LI Chao,LIU Shu-bin.Preparation of Etodolac Double-layer Osmotic Pump Controlled Release Tablet[J].Journal of Shijiazhuang University,2011,13(3):14-17,78. |
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| Authors: | CHANG Ming YUE Hong-kun MU Wei LI Chao LIU Shu-bin |
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| Institution: | CHANG Ming,YUE Hong-kun,MU Wei,LI Chao,LIU Shu-bin(School of Chemical Engineering,Shijiazhuang University,Shijiazhuang,Hebei 050035,China) |
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| Abstract: | The preparation of etodolac in two-layer osmotic pump controlled release tablets is studied.Investigation into the factor influencing the release rate of etodolac double-layer osmotic pump controlled release tablets is conducted by a series of single factor experiments.The results show that the optimal formulation is as follows:weight of membrane 15%,PEO 65%,CMS-Na 56 mg,HPMCK100M 45 mg,CP971NF 11.6 mg,PVPK30 22 mg,NaCl 32.5 mg.The repeatability of three batches is good.It is concluded that the self-prepare... |
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| Keywords: | etodolac osmotic pump single factor test |
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