Evaluation of Oxidative Stress in Type 2 Diabetes Mellitus and Follow-up Along with Vitamin E Supplementation |
| |
| Authors: | Sarita N Shinde Vithal N Dhadke Adinath N Suryakar |
| |
| Institution: | (1) Department of Biochemistry, Pad. Dr. D. Y. Patil Medical College and Hospital, Pimpri, Pune, 411018, India;(2) Department of Medicine, Dr. V. M. Medical College, Solapur, India;(3) Department of Biochemistry, Rajashree Chattrapati Shahu Maharaj, Government Medical College, Kolhapur, India |
| |
| Abstract: | Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications.
The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation
on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls.
Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced
glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group
I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were
again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels.
The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II,
those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that
vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications. |
| |
| Keywords: | Oxidative stress Type 2 diabetes mellitus Endothelial dysfunction Vitamin E |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
