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| PKC在运动性免疫抑制发生过程中的作用 | |
| 引用本文： | 苏利强,张玮,赵广高,郑里翔,严志宏.PKC在运动性免疫抑制发生过程中的作用[J].上海体育学院学报,2011,35(3). |
| 作者姓名： | 苏利强 张玮 赵广高 郑里翔 严志宏 |
| 作者单位： | 1. 江西中医学院体育教学部,江西南昌,330004 2. 南昌大学教育学院体育系,江西南昌,330031 3. 江西中医学院基础医学院,江西南昌,330004 4. 江西中医学院现代中药制剂教育部重点实验室,江西南昌,330004 |
| 基金项目： | 江西省教育厅科学技术研究项目 |
| 摘 要： | 目的:讨论PKC在运动性免疫抑制发生过程中的作用.方法:随机将动物分成正常对照组(A组),反复力竭组(B组),中等强度运动组(C组),每组8只.B组动物完成10 d递增运动至反复力竭,C组动物完成中等强度运动10 d,在末次运动后8 h取外周血和脾脏,分离血清测试IFN-γ、IL-4,脾脏分离淋巴细胞,裂解后测试P-PKC含量.结果:B组淋巴细胞PKC磷酸化程度显著低于A组(P＜0.01),C组显著高于B组(P＜0.01).B、C组的IFN-γ含量均显著低于A组,而C组显著高于B组(P＜0.05).C组IL-4显著低于A组(P＜0.01)和B组(P＜0.05).IFN-γ/IL-4比值B组显著低于A组(P＜0.05),C组显著高于B组(P＜0.01).结论:中等强度运动对Th1/Th2平衡和PKC活性影响不大,没有导致运动性免疫抑制,递增负荷运动至反复力竭可使Th1/Th2平衡向Th2方向漂移,使体液免疫相对亢进,表现运动性免疫抑制,这可能与PKC活性显著降低有关. |
| 关 键 词： | 运动性免疫抑制 蛋白激酶C 干扰素γ 白介素4 |
Effects of PKC on Process of Mobility Immune Suppression |
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| SU Li-qiang,ZHANG Wei,ZHAO Guang-gao,ZHENG Li-xiang,YAN Zhi-hong.Effects of PKC on Process of Mobility Immune Suppression[J].Journal of Shanghai Physical Education Institute,2011,35(3). | |
| Authors: | SU Li-qiang ZHANG Wei ZHAO Guang-gao ZHENG Li-xiang YAN Zhi-hong |
| Institution: | SU Li-qiang,ZHANG Wei,ZHAO Guanggao,ZHENG Li-xiang,YAN Zhi-hong 1.Department of Physical Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi,China,2.Department of Physical Education,College of Education,Nanchang University,Nanchang 330031,3.School of Basic Medical Science,Jianxi University of Traditional Chinese Medicine,4.Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jianxi University of Traditional Chinese Medi... |
| Abstract: | Purpose:The present study discussed the effects of PKC on the process of mobility immune suppression.Methods:Animals were randomly divided into the normal control group(Group A), repeated exhaustion group(Group B)and medium intensity movements(Group C),with 8 rats in each group.After Group B were treated with activity with increasing training load repeatedly till exhaustion for 10 days and Group C with medium load activity for 10 days,peripheral blood and spleen were obtained from Group B and Group C 8 hour... |
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