Proxidant and antioxidant status in patients of type II Diabetes Mellitus with IHD |
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| Authors: | Madhur Gupta Suresh Chari |
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| Institution: | (1) Department of Biochemistry, Indira Gandhi Medical College and NKPSIMS, 53/C/1 Gokulpeth, 440 010 Nagpur |
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| Abstract: | Patients with type II Diabetes Mellitus (NIDDM) are more prone to Ischaemic Heart Disease (IHD). Although, oxygen free radicals
are known to contribute to the development of IHD, conflicting reports are available regarding the antioxidant status in patients
of NIDDM complicated with IHD. This study was undertaken to investigate the oxidative status in patients of NIDDM and to assess
their correlation with plasma glucose, glycosylated haemoglobin and duration of diabetes. The levels of malondialdehyde were
significantly increased where as levels of superoxide dismutase, Glutathione peroxidase and vitamin C were significantly decreased
in diabetics without complications and non-diabetics with IHD when compared with the controls. The levels of malondialdehyde
and Glutathione peroxidase were significantly increased where as levels of superoxide dismutase and vitamin C were significantly
decreased in diabetics with IHD when compared with diabetics without complications and non-diabetics with IHD. The implications
of the results are discussed. |
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| Keywords: | Non insulin Dependent Diabetes Mellitus Ischaemic Heart Disease oxidative status |
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