Fulminant type 1 diabetes in China: a case report and review of the literature |
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| Authors: | Feng Yun-fei Yao Mei-fen Li Qi Sun Yan Li Cheng-jiang Shen Jian-guo |
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| Institution: | (1) Graduate School of Medicine, Osaka University, Suita, Japan;(2) First Department of Internal Medicine, Osaka Medial College, Takatsuki, Japan; |
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| Abstract: | Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes, defined as diabetes with an extremely
rapid process of β-cell destruction and progression to hyperglycemia and ketoacidosis. In this report, we present a case of
fulminant type 1 diabetes in a 45-year-old Chinese woman, along with a review of the literature. The patient presented with
sudden onset of polydipsia and polyuria after flu-like symptoms. Findings on admission included a high blood glucose level
and ketoacidosis, but normal HbA1c level. The C-peptide stimulation test showed severe impairment of insulin secretion. Autoantibodies
to glutamic acid decarboxylase (GAD) were negative. These results are compatible with the diagnosis of fulminant type 1 diabetes.
Human leukocyte antigen-DR7 (HLA-DR7) was available in this case. It is concluded that this rapidly progressing type of diabetes
exists, and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients. |
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| Keywords: | Fulminant type 1 diabetes Diabetic ketoacidosis Flu-like symptoms |
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