| 三七总皂苷对自发性高血压大鼠肾损害干预作用的实验研究 |
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| 引用本文： | 谢燕萍,杨慧文.三七总皂苷对自发性高血压大鼠肾损害干预作用的实验研究[J].宜春学院学报,2012,34(4):62-63,85. |
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| 作者姓名： | 谢燕萍 杨慧文 |
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| 作者单位： | 1. 佛山市第一人民医院药学部,广东佛山,528000
2. 广东药学院,广州,510006 |
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| 摘 要： | 目的:观察三七总皂苷对自发性高血压大鼠肾损害的干预作用。方法:自发性高血压肾损害大鼠30只和正常血压大鼠10只,分成4组,分别灌胃相应剂量的三七总皂苷或生理盐水;给药期间行血压监测,8周后,测定尿MA、β2-MG和血清SCr、BUN、UA。结果:与模型组比较,三七总皂苷组大鼠血压及尿MA、β2-MG和血清SCr、BUN、UA水平明显降低(P<0.05或P<0.01),在一定范围内降低程度与三七总皂苷剂量成正比关系。结论:三七总皂苷能干预自发性高血压大鼠多项肾功能指标,发挥肾功能保护作用。
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| 关 键 词： | 三七总皂苷 自发性高血压 肾损害 |
The Interventive Effect of Panax Notoginseng Saponins on Renal Damage of Spontaneously Hypertensive Rats:an Experimental Research |
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| XIE Yanping,YANG Hui-wen.The Interventive Effect of Panax Notoginseng Saponins on Renal Damage of Spontaneously Hypertensive Rats:an Experimental Research[J].Journal of Yichun University,2012,34(4):62-63,85. |
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| Authors: | XIE Yanping YANG Hui-wen |
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| Institution: | 1.Department of Pharmacy;the First People’s Hospital of Foshan;Guangdong Foshan 528000,China; 2.Guangdong Pharmaceutical University,Guangzhou 510006,China) |
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| Abstract: | Objective: To observe the interventive effect of panax notoginseng saponins(PNS) on renal damage of spontaneously hypertensive rats.Methods: 30 spontaneously hypertensive rats and 10 normal rats were divided into 4 groups and they were given corresponding dose of panax notoginseng saponins(PNS) or normal saline by gastric lavage.Blood pressure monitoring was given in the period of administration.Uric MA,uricβ2-MG,serum SCr,serum BUN and serum UA were determined eight weeks later.Results: Compared with the control group,blood pressure,uric MA,Uricβ2-MG,serum SCr,serum BUN and serum UA significantly decreased in PNS group(P<0.05 or P<0.01) and the decreasing was positively correlated with the dose of PNS in certain range.Conclusion:PNS has effect on renal function indicators of spontaneously hypertensive rats and it has renal protective effect. |
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| Keywords: | panax notoginseng saponins spontaneous hypertension renal damage |
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