| 不同运动负荷大鼠心肌胶原纤维的组织学变化 |
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| 引用本文： | 马宇峰.不同运动负荷大鼠心肌胶原纤维的组织学变化[J].山东体育学院学报,2005,21(5):58-61. |
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| 作者姓名： | 马宇峰 |
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| 作者单位： | 郑州大学体育学院,河南,郑州,450000 |
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| 摘 要： | 为探讨心室肌胶原纤维的组成、分布以及对心功能的影响，观察不同运动负荷下心肌间质胶原纤维的变化，选用雄性大鼠36只，随机分为对照组、一般运动负荷组和超负荷组，每组12只.各运动组训练满8周后，分别取左心室前壁、左心室乳头肌，常规固定，石蜡包埋、制片，用Masson染色光镜观察并进行图像分析.发现对照组胶原纤维走行及分布均匀;一般负荷组胶原纤维增多，在细胞周围呈环状分布，胶原纤维鞘上纤维母细胞增多;超负荷组胶原纤维明显增多，在心肌细胞周围呈条索状广泛分布（P＜0.01）.得出结论：胶原纤维结构改变是很多心脏病理状态的重要特征，随运动负荷的增加，心肌间质胶原纤维显著增加，心肌结构发生明显改建。
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| 关 键 词： | 大鼠 运动负荷 心肌间质 胶原纤维 |
| 文章编号： | 1006-2076(2005)05-58-04 |
| 收稿时间： | 06 17 2005 12:00AM |
| 修稿时间： | 2005年6月17日 |
Histologic changes of different exercise patience on myocardial collagenous fibers in rats |
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| MA Yu-feng.Histologic changes of different exercise patience on myocardial collagenous fibers in rats[J].Journal of Shandong Physical Education Institute,2005,21(5):58-61. |
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| Authors: | MA Yu-feng |
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| Institution: | Inst. of PE, Zhengzhou University, Zhengzhou 400065, China |
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| Abstract: | Objective:To probe into the constitution and distribution of the collagen fiber on the substance of ventricle muscle,to investigate the impact of collagen fiber on heart function and to observe the collagen fiber's changes loaded different movement force.Method:1.Thirty-six adult male mice were selected randomly and divided into three groups,that is control group,generally trained group and overloaded group with 12 in each group.2.Decollation after full eight-week training,the left ventricular front wall,left nipple muscle,arch of aorta were selected respectively.Fixing-dehydrating-transparency-embed-slice were performed.3.Masson staining,and analyses the picture with HPIAS-1000 computer image analytical system.Result:Control(group's) collagen fiber was well-distributed.general trained group's collagen tow increase obviously,presenting circle-type distribution master fibers on the collagen fiber whiplash cell increased and the shape of the collagen fiber network changes obviously by contrast.The overloaded group's collagen fiber increases obviously and formed between some myocardial cells with strip distribution(P<0.01).Conclusion:The structure changes of collagen fiber are important characteristic of heart in pathology condition.With the increase of movement force,the collagen fiber of myocardial interstitial increases notably,and the obvious shanges of heart structure are taken place. |
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| Keywords: | adult male mice movement force myocardial interstitial collagen fiber |
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