Lipid abnormalities,lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease |
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| Authors: | A Madhusudhana Rao A R Bitla E P Reddy V Sivakumar P V L N Srinivasa Rao |
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| Institution: | (1) Faculty of Medicine, Clinical Pathology Department, Cairo University, Cairo, Egypt;(2) Clinical Chemistry Department, Theodor Bilharz Research Institute, Cairo, Egypt;(3) Nephrology Department, Theodor Bilharz Research Institute, Cairo, Egypt;(4) Intensive Care Department, Theodor Bilharz Research Institute, Cairo, Egypt |
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| Abstract: | The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein
(a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2
(stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects
as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and
2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05).
However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI
values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in
group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05).
In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are
the major lipid disorders in the development of cardiovascular complications at all the stages in these patients. |
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