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| 甘草次酸衍生物的合成与表征 | |
| 引用本文： | 赵龙铉,张晓翠,赵春晖,沈平,杨君微,唐尧.甘草次酸衍生物的合成与表征[J].大连大学学报,2011,32(3):40-43,71. |
| 作者姓名： | 赵龙铉 张晓翠 赵春晖 沈平 杨君微 唐尧 |
| 作者单位： | 1. 辽宁师范大学化学化工学院,辽宁大连116029;辽宁师范大学生物技术与分子药物研发辽宁省重点实验室,辽宁大连116029 2. 辽宁师范大学化学化工学院,辽宁大连,116029 3. 辽宁师范大学生物技术与分子药物研发辽宁省重点实验室,辽宁大连,116029 |
| 摘 要： | 甘草次酸属于五环三萜类化合物,是多种天然产物的功能性成分,在自然界中分布广泛,并显示出多种生物活性,如：保肝、抗癌、抗炎、抗菌、抗病毒等多种药理作用,并具有良好的抗癌活性,且本身毒性较低。甘草次酸已被应用于临床,药用开发前景广阔。因此,本文以甘草次酸为先导化合物,在其C-3位进行了结构修饰,偶联了氨基酸以提高其水溶性,共合成了3种新的中间体和3种新的目标产物,并利用IR和~1H NMR波谱技术对其结构进行了表征。 |
| 关 键 词： | 甘草次酸 衍生物 合成 |
Synthesis and Characterization of Glycyrrhetinic Acid Derivatives |
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| ZHAO Long-xuan,ZHANG Xiao-cui,ZHAO Chun-hui,SHEN Ping,YANG Jun-wei,TANG Yao.Synthesis and Characterization of Glycyrrhetinic Acid Derivatives[J].Journal of Dalian University,2011,32(3):40-43,71. | |
| Authors: | ZHAO Long-xuan ZHANG Xiao-cui ZHAO Chun-hui SHEN Ping YANG Jun-wei TANG Yao |
| Institution: | 1 (1.School of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian 116029,China; 2.Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery,Liaoning Normal University,Dalian 116029, China) |
| Abstract: | Glycyrrhetinic acid belongs to pentacyclic triterpenoid compounds.It's the functional ingredients of many natural products.The glycyrrhetinic acid is widely distributed in nature,and shows a variety of biological activities,such as:liver,anti-cancer anti-inflammatory,antibacterial,antiviral and other pharmacological effects,and with good antitumor activity.Its toxicity is low.Glycyrrhetinic acid has been used in clinical and has a large pharmaceutical development prospect.Therefore,we used glycyrrhetinic acid as a leading compound and had the structural modification on C-3,coupling of amino acids to improve its water-soluble. We synthesis three of intermediates and three final products and IR and ~1H NMR spectroscopy techniques were used to characterize their structure. |
| Keywords: | glycyrrhetinic acid derivatives synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |