Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants |
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| Authors: | Dan-li Fu Qiao-hong Jiang Fu-ming He Guo-li Yang and Li Liu |
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| Institution: | 1Department of General Dentistry, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China;2Department of Oral Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China;3Department of Prosthodontics, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China |
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| Abstract: | The purpose of this study was to analyze the effect of strontium-substituted hydroxyapatite (Sr-HA) on bone osseointegration
of the implants using fluorescence microscopy. We allocated 20 implants to two groups: Sr-HA group and HA group. Electrochemically
deposited HA and Sr-HA coatings were applied onto the implants separately. All the implants were inserted into femur bone
of rabbits. Oxytetracycline hydrochloride, alizarin-complexon, and calcein green were respectively administered 7, 28, and
46 d after the implantation. After eight weeks, femurs were retrieved and prepared for the fluorescence microscopy observation.
We analyzed the bone mineral apposition rates (MARs), bone area ratios (BARs), and bone to implant contact (BIC) of the two
groups. Fluorescence microscopic observation showed that all groups exhibited extensive early peri-implant bone formation.
The MAR of the Sr-HA group was greater than that for pure HA from 7 to 28 d after implantation, but no significant difference
was found at later stage. And the BIC showed difference at 7 and 28 d compared with pure HA. We concluded that Sr-HA coating
can improve the bone osseointegration of the implant in the early stage compared with the HA coating. |
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| Keywords: | Strontium-substituted hydroxyapatite Hydroxyapatite Osseointegration |
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