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| 缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究 | |
| 引用本文： | 黄碧玉,吴海臣,杨镜奎.缺电子Rh-BINAP催化剂催化氢化富电性底物的机理研究[J].中国科学院研究生院学报,2012,29(4):571-575. |
| 作者姓名： | 黄碧玉 吴海臣 杨镜奎 |
| 作者单位： | 1. 中国科学院研究生院化学与化学工程学院,北京100049;中国科学院高能物理研究所,北京100049 2. 中国科学院高能物理研究所,北京,100049 3. 中国科学院研究生院化学与化学工程学院,北京,100049 |
| 基金项目： | Supported by the Project of the National Natural Science Foundation of China(20972159);the President Fund of GUCAS |
| 摘 要： | 合成了4种富电性的脱氢α-氨基酸衍生物,将缺电子催化剂Rh-3,5-CF3- (R) -BINAP用于这几种底物的不对称氢化反应中.讨论了底物上取代基及空间位阻对对映选择性的影响. |
| 关 键 词： | 富电性底物 缺电子催化剂 不对称氢化 机理 |
Mechanistic study on hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst |
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| HUANG Bi-Yu , WU Hai-Chen , YANG Jing-Kui.Mechanistic study on hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst[J].Journal of the Graduate School of the Chinese Academy of Sciences,2012,29(4):571-575. | |
| Authors: | HUANG Bi-Yu WU Hai-Chen YANG Jing-Kui |
| Institution: | 1(1 College of Chemistry and Chemical Engineering,Graduate University,Chinese Academy of Sciences,Beijing 100049,China;2 Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China) |
| Abstract: | Four electron-rich α-acetamidocinnamic acid derivatives were prepared and used as substrates in the asymmetric hydrogenation catalyzed by electron-deficient Rh-3,5-CF3-(R)-BINAP.Influence of the electronic properties of substituted groups in the substrates and their steric hindrance on the enantioselectivity of the product were discussed. |
| Keywords: | electron-rich substrates electron-deficient Rh-BINAP catalyst asymmetric hydrogenation mechanism |
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