| 线粒体融合蛋白Mfn2与胰导素抵抗 |
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| 引用本文： | 宫克城,丁树哲.线粒体融合蛋白Mfn2与胰导素抵抗[J].冰雪运动,2009,31(1):52-55. |
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| 作者姓名： | 宫克城 丁树哲 |
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| 作者单位： | 华东师范大学,体育与健康学院,上海,200241 |
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| 摘 要： | 线粒体融合蛋白-2具有促进线粒体融合、抑制细胞增殖、保护细胞免于凋亡等多种功能。越来越多的证据表明,该基因产物与胰岛素抵抗状态有关。目前对于线粒体融合蛋白-2的研究,已成为2型糖尿病领域研究的热点,为2型糖尿病的预防和治疗提供了新的生理和药理作用靶点。综述了胰岛素抵抗发生与运动防治中的作用,旨在为2型糖尿病的治疗提供理论依据。
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| 关 键 词： | 粒体融合蛋白-2 线粒体融合 胰岛素抵抗 运动 |
Mitochondria Fusion Protein Mfn2 and Insulin Counteraction |
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| GONG Ke-cheng,DING Shu-zhe.Mitochondria Fusion Protein Mfn2 and Insulin Counteraction[J].China Winter Sports,2009,31(1):52-55. |
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| Authors: | GONG Ke-cheng DING Shu-zhe |
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| Institution: | GONG Ke-cheng,DING Shu-zhe(Sports Healthy School of East China Normal University,Shanghai 200241,China) |
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| Abstract: | Several functions of the mitochondria fusion protein Mfn2 have been found,such as promoting mitochondria fusion,inhibiting cell proliferation and protecting cell against apoptosis. More and more evidence suggest that it is involved in insulin counteraction. Now,the study of mitofusin 2 has become a hotspot in the field of type 2 diabetes research,which provides a new physiological and pharmacological function spot for the treatment and prevention of type 2 diabetes. Roles of Mitofusin 2 on the pathogenesis,... |
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| Keywords: | Mfn2 mitochondria fusion insulin Counteraction movement |
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