| 6-APA中残余苯乙酸、青霉素G含量的测定 |
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| 引用本文： | 赵国芬,尹翠英,王洪涛.6-APA中残余苯乙酸、青霉素G含量的测定[J].石家庄职业技术学院学报,2008,20(4):15-17. |
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| 作者姓名： | 赵国芬 尹翠英 王洪涛 |
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| 作者单位： | 石药集团中润制药有限公司,质量检验部,河北,石家庄,050041 |
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| 摘 要： | 采用高效液相色谱法对6-APA中残余苯乙酸、青霉素G含量进行了测定.经验证,此方法具有较强的专属性,苯乙酸、青霉素G测量的线性范围分别为0.000 499 7～0.013 991 6 mg/mL和0.000 501 3～0.014 036 4mg/mL;苯乙酸的回收率为99.91%,青霉素G的回收率为85.86%;苯乙酸、青霉素G的定量限分别为0.003 198mg/mL和0.001 004 mg/mL,检出限分别为：0.000 301 2 mg/mL和0.000 959 4 mg/mL.
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| 关 键 词： | 6-APA 高效液相色谱法 苯乙酸 青霉素G |
Determination of the residual phenylacetic acid and penicillin G in 6-APA |
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| ZHAO Guo-fen,YIN Cui-ying,WANG Hong-tao.Determination of the residual phenylacetic acid and penicillin G in 6-APA[J].Journal of Shijiazhuang Vocational Technology Institute,2008,20(4):15-17. |
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| Authors: | ZHAO Guo-fen YIN Cui-ying WANG Hong-tao |
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| Institution: | ZHAO Guo-fen,YIN Cui-ying,WANG Hong-tao (Department of Quality Control,Zhongrun Co.,Ltd.of Shijiazhuang Pharmaceutical Group,Shijiazhuang,Hebei 050041,China) |
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| Abstract: | The residual phenylacetic acid(PAA) and penicillin G(PCG) are measured in 6-APA by high performance liquid chromatography.By validation,this has a good specification.The linear concentration ranges of PAA and PCG are 0.000 499 7-0.013 991 6 mg/mL,0.000 501 3-0.014 036 4 mg/mL respectively,the average recoveries 99.91%,85.86% respectively,the limits of quantitation 0.003 198 mg/mL,0.001 004 mg/mL respectively,and the limits of detection 0.000 301 2 mg/mL,0.000 959 4 mg/mL respectively. |
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| Keywords: | 6 -APA |
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