| 咪达唑仑预防腰-硬联合麻醉妇科手术后恶心呕吐的随机双盲研究 |
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| 引用本文： | 白芬芬,黄科昌,杨洪光,丰磊,杨伟伟.咪达唑仑预防腰-硬联合麻醉妇科手术后恶心呕吐的随机双盲研究[J].潍坊教育学院学报,2009(2):132-134. |
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| 作者姓名： | 白芬芬 黄科昌 杨洪光 丰磊 杨伟伟 |
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| 作者单位： | [1]潍坊医学院麻醉学系,山东潍坊261042 [2]潍坊医学院附属医院麻醉科,山东潍坊261042 [3]青岛市立医院麻醉科,山东潍坊261042 |
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| 摘 要： | 目的观察咪达唑仑预防腰-硬联合麻醉下妇科手术后恶心呕吐的效果。方法腰-硬联合麻醉妇科手术患者90例，随机分为M（咪达唑仑）组、G（格拉斯琼）组和NS组，手术结束时分别静注咪迭唑仑2mg，格拉斯琼3rag和生理盐水3ml，10min后开始硬膜外自控镇痛（PCEA），观察病人术后24h内恶心呕吐和镇静情况。结果NS组患者恶心呕吐总发生率（56．7％）显著高于其他两组（P〈0．01），M组（32．3％）和G组（24．1％）差异无统计学意义（P〉0．05）。术后2h时M组镇静程度高于C组和NS组（P〈0．05），但Ramsay评分均未超过3分；4h时3组病人镇静程度相近。结论腰-硬联合麻醉下行妇科手术的病人手术结束时静脉注射咪达唑仑2mg可以有效预防术后恶心呕吐，其效果和格拉斯琼3mg相似，且未表现出明显的镇静作用。
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| 关 键 词： | 咪达唑仑 腰-硬联合麻醉 恶心呕吐 外科手术 妇科 |
A Randomized and Double-Blind Study on the Antiemetic Efficacy of Midazolam Preventing Postoperative Nauseaand Vomiting in Patients Undergoing Gynaecological Surgery |
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| BAI Fen-fen,HUANG Ke-chang,YANG Hong-guang,FENG Lei,YANG Wei-wei.A Randomized and Double-Blind Study on the Antiemetic Efficacy of Midazolam Preventing Postoperative Nauseaand Vomiting in Patients Undergoing Gynaecological Surgery[J].Journal of Weifang Educational College,2009(2):132-134. |
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| Authors: | BAI Fen-fen HUANG Ke-chang YANG Hong-guang FENG Lei YANG Wei-wei |
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| Institution: | BAI Fen-fen, HUANG Ke-chang, YANG Hong-guang, FENG Lei, YANG Wei-wei (1.Department of Anesthesiology Weifang Medical College, Weifang 261053, China; 2 The Affiliated Hospital of Weifang Medical College ; 3 Qingdao Municipal Hospital ) |
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| Abstract: | Objective To compare the antiemetic efficacy of midazolam with granisetron and normal sodium for the treatment of postoperative nausea and vomiting（ PONV）. Methods Ninety patients scheduled for elective gynaecological surgery under combined spinal epidural analgesia were randomized to receive intravenous midazolam 2mg in Group M,granisetron 3mg in Group G and normal saline 3ml in Group NS at the end of the surgery. Patient controlled epidural analgesia（PCEA） was maintained for remaining 48h. Results The incidence of PONV was significantly lower in Group M（32.3% ） and Group G（24.1% ） than that in Group NS（56.7% ） in the first 24th（ P 〈0.01 ） ,but there was no statistical difference between Group M and Group G. Sedation scores was higher in Group M than those in Group G and Group NS at 2h after the surgery（P 〈 0.05 ）. There were no significant differences in average sedation scores among the groups at 4 h after the surgery. Conclusion Midazolam 2mg is as effective as granisetron 3mg in preventing PONV in patients undergoing gynaecological surgery without untoward sedative effects. |
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| Keywords: | Midazolam Combined spinal epidural anaesthesia Postoperative nausea and vomiting Surgery gynecological |
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