| Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart |
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| 作者姓名： | 王建安 李长岭 樊友启 何红 孙勇 |
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| 作者单位： | Department of Cardiology，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Department of Cardiology，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Department of Cardiology，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Department of Cardiology，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Department of Cardiology，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China |
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| 基金项目： | Projects (No. 30240075) supported by the National Natural Science Foundation of China |
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| 摘 要： | Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=17). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn I) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality 35% (7/20) (P<0.05)]. Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group
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Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart |
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| WANG Jian-an,LI Chang-ling,FAN You-qi
HE Hong,SUN Yong.Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart[J].Journal of Zhejiang University Science,2004(10). |
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| Authors: | WANG Jian-an LI Chang-ling FAN You-qi
HE Hong SUN Yong |
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| Abstract: | |
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| Keywords: | Bone marrow-derived mesenchymal stem cells Transplantation Myocardial infarction |
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