| 壳聚糖的两亲性衍生物制备及在药物载体方面的应用 |
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| 引用本文： | 姜凌娟,周惠云.壳聚糖的两亲性衍生物制备及在药物载体方面的应用[J].天水师范学院学报,2011,31(5):27-31. |
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| 作者姓名： | 姜凌娟 周惠云 |
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| 作者单位： | 河南科技大学 化工与制药学院,河南 洛阳,471003 |
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| 摘 要： | 壳聚糖由于生物适应性强、生物可降解、原材料丰富等优点被公认为最具发展潜力的生物材料.其两亲性衍生物具有疏水性内核和亲水性外壳的胶束结构,主要用于难溶性药物、抗癌药物的缓控释和靶向载体.综述了近年来壳聚糖两亲性衍生物的制备和在药物载体方面的应用,并对其发展趋势和应用前景作了简单评述.
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| 关 键 词： | 壳聚糖 两亲性 药物载体 |
Preparation of Chitosan Amphiphilic Derivative and Its Application in Pharmaceutical Carrier |
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| Jiang Lingjuan
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Zhou Huiyun.Preparation of Chitosan Amphiphilic Derivative and Its Application in Pharmaceutical Carrier[J].Journal of Tianshui Normal University,2011,31(5):27-31. |
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| Authors: | Jiang Lingjuan Zhou Huiyun |
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| Institution: | (College of Chemical Engineering and Pharmaceutics,Henan University of Science and Technology,Luoyang Henan 471003,China) |
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| Abstract: | Chitosan is recogniaze as the most potential biological material because its advantages of strong biological adaptability,biodegradability,richness of raw material,its amphiphilic derivative has the mioellar structure of hydrophobic kernel and hydrophilic shell and is applied in slightly solubility drug,slow and control release of anticancerdrug and targeted carrier.The preparation of chitosan derivative and its application in pharmaceutical carrier were summarized in recent years and its development tendency and appilication prospect were discussed finally in this paper. |
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| Keywords: | chitosan amphiphilic pharmaceutical carrier |
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