| 干血点技术在反兴奋剂领域的应用研究与前景展望 |
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| 引用本文： | 荆京,单圆鸿,陈佩杰,徐昕.干血点技术在反兴奋剂领域的应用研究与前景展望[J].上海体育学院学报,2021(2):22-31. |
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| 作者姓名： | 荆京 单圆鸿 陈佩杰 徐昕 |
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| 作者单位： | 上海体育学院国家兴奋剂检测上海实验室（筹） |
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| 基金项目： | 国家重点研发计划“科技冬奥”专项课题(2020YFF0304500)。 |
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| 摘 要： | 作为一种血液样本的替代采集方法,干血点(dried blood spot,DBS)采样技术在新生儿筛查以及临床和药学等领域被广泛应用,同时在反兴奋剂领域也受到了关注。为进一步了解DBS在运动员样本的采集、运输、保存等方面的潜在优势以及在兴奋剂检测中的研究现状,对近10年的相关文献资料进行归纳总结,发现DBS技术具有操作简单、血量需求少、微创性、易保存与运输等优势,克服了传统采样方法的诸多缺点;同时,DBS与液相色谱和质谱技术联用在各类禁用物质检测中也显示出一定优势,DBS是一种良好的替代或补充基质。就DBS在当前应用中面临的难点以及可能的解决方法进行探讨,并对DBS在反兴奋剂领域的应用前景进行展望。
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| 关 键 词： | 干血点技术 液相色谱质谱方法 兴奋剂检测 运动员 |
Research and Prospect of Dried Blood Spot TechnologyApplication toAnti-Doping |
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| JING Jing,SHAN Yuanhong,CHEN Peijie,XU Xin.Research and Prospect of Dried Blood Spot TechnologyApplication toAnti-Doping[J].Journal of Shanghai Physical Education Institute,2021(2):22-31. |
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| Authors: | JING Jing SHAN Yuanhong CHEN Peijie XU Xin |
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| Institution: | (Shanghai Anti-Doping Laboratory,Shanghai University of Sport,Shanghai 200438,China) |
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| Abstract: | Dried blood spot(DBS)technology,as an alternative method of blood collection,has been widely used in neonatal screening and other clinical or pharmaceutical research fields.DBS has also drawn some attention in the field of anti-doping recently.For the purpose of examining the potential advantage in blood collection,transportation and storage,the current research development of DBS in doping detection,the 10-year literature data are summarized.It finds that the DBS simplifies sample collection,storage and transportation.And it needs a smaller blood volume with minor hurt only,which offers a number of advantages over conventional blood sampling.The combined application of DBS and LC-MS technology also shows advantages in the detection of various prohibited substances.In addition,the difficulties and potential application of DBS in the field of anti-doping are also discussed,trying to provide references for its further prospect. |
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| Keywords: | DBS technology LC-MS doping control athlete |
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