Oxidative stress, α-tocopherol, ascorbic acid and reduced glutathione status in schizophrenics |
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| Authors: | Gora Dadheech Sandhya Mishra Shiv Gautam Praveen Sharma |
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| Institution: | (1) Department of Biochemistry, S. M. S. Medical College and Hospital, 302004 Jaipur, (Rajasthan), India;(2) Department of Psychiatry, S. M. S. Medical College and Hospital, 302004 Jaipur, (Rajasthan), India |
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| Abstract: | A disturbance in the antioxidant defense system including α-tocopherol, ascorbic acid and reduced glutahtione metabolism due
to free radical induced oxidative injury has been implicated in various neuro-psychiatric disorders. The roles of these antioxidants,
changes in their blood levels and correlation with oxidative stress were studied in a common psychiatric illness Schizophrenia.
Fifty-eight subjects of either sex ranging in age from 18–60 years divided into two age groups (≤40 and >40 years) diagnosed
for schizophrenia, and forty age and sex-matched normal subjects as controls were included in the study. Blood samples were
analyzed for malondialdehyde (MDA), α-tocopherol, total ascorbic acid (TAA), dehydro ascorbic acid (DHAA), reduced ascorbic
acid (RAA), leucocyte ascorbic acid (LAA) and reduced glutathione (GSH). A decrease in the levels of α-tocopherol, total ascorbic
acid and reduced glutathione was found in schizophrenics compared to normal controls. Further a significant rise in oxidative
stress and decreased antioxidant status was observed in the chronic stage of schizophrenia as compared to those in acute condition.
A significant rise in dehydroascorbic acid with concomitant fall in reduced ascorbic acid suggests scavenging action of ascorbic
acid and its utilization with increased oxidative stress as indicated by high blood malondialdehyde levels. Leucocyte ascorbic
acid, a better index of ascorbic acid status was also found to be reduced in schizophrenics, suggesting depletion of body
stores of ascorbic acid and the condition worsened with advancing age. |
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| Keywords: | Oxidative stress Malondialdehyde α -tocopherol Ascorbic acid Dehydroascorbic acid Glutathione Schizophrenia |
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