Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections |
| |
| Authors: | Saba Khan Arpit Bhargava Neelam Pathak Kewal K Maudar Subodh Varshney Pradyumna K Mishra |
| |
| Institution: | (1) Bhopal Memorial Hospital & Research Centre, Bhopal, India;(2) Present address: Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, 410 210, India; |
| |
| Abstract: | The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered
a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients
was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and
circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its
kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections.
Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however,
role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk
individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our
study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma. |
| |
| Keywords: | Hepatitis Nucleosomes Hepatocellular carcinoma Translational research Biomarkers |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
