Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease |
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| Authors: | Cho Jun Y Hwang Dae Y Kang Tae S Shin Dong H Hwang Jin H Lim Chae H Lee Su H Lim Hwa J Min Sae H Seo Su J Song Youn S Nam Ki T Lee Kyu S Cho Jung S Kim Yong K |
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| Institution: | Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Seoul 122-704, Korea. |
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| Abstract: | In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on A beta-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of A beta-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease. |
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