Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy |
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| Authors: | H R Mali S A Siddiqui Madhur Garg R K Singh M L B Bhatt |
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| Institution: | (1) Department of Radiotherapy, King George's Medical College, 226003 Lucknow;(2) Department of Biochemistry, King George's Medical College, 226003 Lucknow;(3) Department of Radiotherapy, J. N. Medical College, Aligarh Muslim University, Aligarh |
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| Abstract: | Present study repots changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated
SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls.
Patients received radiation in doses of 40–70 Gy in 4–7 weeks. SCLs were again estimated in patients following irradiation.
The mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly
(P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest
fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation
of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment. |
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| Keywords: | Serum copper malignancy radiotherapy |
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