A Comparative Study of Clinical Utility of Spot Urine Samples with 24-h Urine Albumin Excretion for Screening of Microalbuminuria in Type 2 Diabetic Patients |
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| Authors: | Vilas U Chavan Pushpa P Durgawale Anjum K Sayyed Ajit V Sontakke Nazir R Attar Swati B Patel Sangita R Patil Shreyasprasad D Nilakhe |
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| Institution: | (1) Department of Biochemistry, Surat Municipal Institute of Medical Education & Research (SMIMER), A-Block, Opp to Bombay Market, Umarwada, Surat, 395010, Gujarat, India;(2) Department of Biochemistry, KIMS, Karad, Maharashtra, India;(3) Department of Medicine, K.S. Hegde Medical Academy and K.S. Hegde Hospital Deralkatte, Mangalore, Karnataka, India;(4) Department of Community Medicine, SMIMER, Surat, Gujarat, India |
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| Abstract: | Twenty-four hour urinary albumin excretion (UAE) is considered as gold standard method for albuminuria measurement, but collection
of 24-h urine is inconvenient. The aim of present study was to evaluate whether albumin: creatinine ratio (ACR) and urinary
albumin concentration (UAC) in different spot urine samples correlate or not with 24-h UAE for screening of microalbuminuria
in type 2 diabetic patients. We collected first morning void (FMV), random urine sample (RUS) and 24-h urine, separately on
consecutive days from 104 type 2 diabetic patients. ACR and UAC in each spot urine sample compared with 24-h UAE with regard
to Pearson correlation coefficient. Pearson’s correlation of albumin: creatinine ratio (ACR) with 24-h UAE was (r = 0.802 and 0.623) in first morning void (FMV) and random urine sample (RUS), respectively. Pearson’s correlation coefficient
of urinary albumin concentration (UAC) compared with 24-h UAE was (r = 0.943 and 0.920), in FMV and RUS, respectively, P < 0.01. Results revealed that values in first morning void (FMV) were better correlated with 24-h urinary albumin excretion
(UAE), than the values in random urine sample (RUS). We conclude that the first morning void (FMV) may be able to replace
24-h urine collection, preferably urinary albumin concentration (UAC) in the initial screening of microalbuminuria in diabetic
patients. |
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| Keywords: | Diabetes mellitus Microalbuminuria Screening Spot urine sample Urinary albumin concentration |
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