| KCNJ11基因多态性与2型糖尿病的关联研究 |
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| 引用本文： | 彭姝彬,苏燕,韩大良,张乍如.KCNJ11基因多态性与2型糖尿病的关联研究[J].岳阳职业技术学院学报,2008,23(4). |
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| 作者姓名： | 彭姝彬 苏燕 韩大良 张乍如 |
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| 作者单位： | 1. 岳阳职业技术学院,湖南,岳阳,414000
2. 华中师范大学生命科学学院,湖北,武汉,430079 |
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| 摘 要： | 目的：探讨β-细胞腺苷三磷酸一敏感性钾通道（potassium inwardly—rectifying channel，subfamilyl，member 11，KCNJ11）基因E23K多态性与湖北汉族人群2型糖尿病的相关性。方法：采用同胞对（家系内对照）和随机病例一对照两种实验设计，利用聚合酶链式反应-限制性片段长度多态性（PCR—RFLP）技术分析湖北地区443例样本KCNJ11基因E23K多态性。并测定身高、体重、腰围、臀围、血压和空腹血糖等生理生化指标。结果：随机病例一对照实验设计中，病例组与对照组的基因型频率与等位基因频率有显著性差异（P〈0．05或P〈0.01）。结论：在湖北汉族人群中，2型糖尿病的发生发展与KCNJ11基因E23K多态性相关联，KCNJ11基因是湖北汉族人的一个2型糖尿病易感基因。
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| 关 键 词： | 2型糖尿病 KCNJ11基因 关联 多态性 |
Association Analyses of KCNJ11 Gene Polymorphisms with Type 2 Diabetes Mellitus |
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| PENG Shu-bin SU Yan HAN Da-liang ZHANG Zha-ru . College of Life Science,Central China Normal University,Wuhan,Hubei.Association Analyses of KCNJ11 Gene Polymorphisms with Type 2 Diabetes Mellitus[J].Yueyang Vocational Technical College,2008,23(4). |
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| Authors: | PENG Shu-bin SU Yan HAN Da-liang ZHANG Zha-ru College of Life Science Central China Normal University Wuhan Hubei |
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| Institution: | PENG Shu-bin1 SU Yan2 HAN Da-liang1 ZHANG Zha-ru1 (1. Yueyang Vocational , Technical College,Yueyang,Hunan 414000) 2. College of Life Science,Central China Normal University,Wuhan,Hubei 430079) |
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| Abstract: | Objective: To study the correlation between KCNJ11 E23K polymorphism and T2DM in Han Chinese in Hubei. Methods: Both sib-pairs and random case-control designs were used, the genotypes of KCNJ11 gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 443 samples. Height, weight, blood pressure and fasting blood glucose were measured. Results: There were significant differences in the genotypic and allelic frequencies of the KCNJ11 gene E23K polymorphism between ... |
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| Keywords: | Type 2 Diabetes Mellitus KCNJ11 gene association polymorphism |
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